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    Date submitted
  • 18-Feb-2016

microSiO

Abstract

Our goal is to encapsulate therapeutic molecules into a new class of silicone microparticles for controlled release for augmenting skin health care. We have recently demonstrated the ability to synthesize monodisperse silicone gel particles from nucleation and growth in a highly scalable format [1]. We believe these particles will provide new and exciting opportunities for drug and small molecule delivery due to their ability to efficiently encapsulate certain small molecules (e.g., Vitamin A), their programmable properties for controlling release rates, and their known low toxicity to the body. Our business strategy is to tailor the properties of these particles to uptake various therapeutic compounds (e.g., vitamins and anti-aging compounds) for integration into current commercial products like lotions and creams to impart improved health benefits.

[1] Shields, W.; Sun, D.; Johnson, K.; Korine, D. et al. Angew Chemie Intl Ed, 2014, 53, 8070-8073

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Original YouTube URL: Open

Introduction Video

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Additional Questions

Who is your customer?

Our consumers include, but are not limited to, skin and health care product manufacturers. We are developing a cutting-edge microsphere technology that enables controllable release of active ingredients (e.g., anti-aging therapeutic compounds). We are designing these spheres to be integrated into existing products such as lotions and creams for large scale distribution.

What problem does this idea/product solve or what market need does it serve?

Many important small molecules (e.g., Vitamin A) are difficult to deliver in current products as they are unstable and hydrophobic. To overcome this challenge, companies are looking to incorporate various active compounds into microparticles. We have developed a superior microparticle that offers greater control over the uptake and release of various compounds and therapeutic agents.

What attributes will make this idea/product successful? Why do you believe that those features will create success?

Our technology contains a means to program the properties of the microparticles to precisely control the release of various compounds. By tailoring the properties of the particles for a given application, we can optimize the performance of these products for high performance and long-lasting delivery.

Explain how you (your team) will execute to make this idea/product successful? What gives you (your team) an advantage over others already in the market or new to this market?

Our team is comprised of students in the school of business and the department of biomedical engineering at Duke University. Two of the four members of the team are the original inventors of the technology and have substantial expertise in the development and adaptation of these microspheres. We are currently leveraging this knowledge to propel this technology to the next level. Meanwhile, the business students on the team are navigating the progression of this technology by meeting with various leaders and experts in personal care and cosmetics.